Skip to main content
. 2014 Apr 20;140(1):190–203. doi: 10.1093/toxsci/kfu074

Fig. 3.

Fig. 3.

(A) Representative autoradiograph images of Esr2 in the AVPV (indicated by arrow in female vehicle image) of each exposure group. (B) Impact of BPA exposure on Esr2 expression in the PND 90 female AVPV. Esr2 expression was significantly lower in all of the BPA exposed groups except the BPA 2700 group compared with the female vehicle controls. The positive control groups are depicted in (C). Esr2 expression was significantly lower in the male vehicle group compared with the female vehicle group and this sex difference is indicated by the thin line traversing across panels (B) and (C). Expression the three significantly impacted BPA groups was reduced to male-typical levels. Among the EE groups, Esr2 expression was significantly reduced in both the EE 0.5 and EE 5 groups compared with female vehicle controls, with levels approximating those seen in the male vehicle group (n = 10 for all groups; *p ≤ 0.05, **p ≤ 0.01 compared with female vehicle group; sex differences denoted with ††p ≤ 0.01; graph depicts mean ± SEM).