Figure 4.

Cardiomyocyte-restricted STAT3 deletion exacerbates acute-stage DOX cardiotoxicity. (A) FS in saline- and DOX-treated WT and STAT3-CKO mice. X-axis indicates the age of the mice at analysis; vertical arrows indicate the age at DOX injection. *P < 0.05 for DOX-treated WT vs. saline-treated WT mice, ^†P < 0.05 for DOX-treated WT vs. DOX-treated STAT3-CKO mice, ^‡P < 0.05 for DOX-treated STAT3-CKO vs. saline-treated STAT3-CKO mice. (B) Representative short-axis echocardiograms from saline- and DOX-treated WT and STAT3-CKO mice. (C) Quantitation of activated caspase-3 immune reactive cardiomyocytes (CSP⁺ CM) per mm² in hearts from saline- and DOX-treated NON-TXG and STAT3-CKO mice in the acute stage.