Figure 4.
Ex vivo mdx hearts have reduced beta-adrenergic responses at the age of 4 months. Hearts perfused on Langendorff apparatus with different concentrations of ISO (10−12–10−5 M). Heart rates (A), developed pressure (B), maximum +dp/dt (C), and minimum −dp/dt (D) were analysed. (E–H) Normalized data of (A–D). $P < 0.05, $$P < 0.01, $$$P < 0.001 vs. control baseline, respectively; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. mdx baseline, respectively; *P < 0.05, **P < 0.01, ***P < 0.001 control vs. mdx at the same age, respectively. Two-way ANOVAs with repeated measurements and post hoc test (Bonferroni corrections) were performed.