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. 2014 May 8;103(1):178–187. doi: 10.1093/cvr/cvu123

Figure 4.

Figure 4

Impaired local regulation by PP1 increased CaSF in atrial myocytes. (A) Representative confocal line-scan images of atrial myocytes loaded with Fluo4-AM. (B) Bar graph summarizing the ratio of CaSF normalized to SR load for atrial myocytes isolated from WT and Sp−/− mice, in the presence or absence of CaMKII inhibitors KN-93 or AIP, or control drug KN-92. (C) Bar graph comparing the ratio of CaSF to SR load in atrial myocytes paced at 1 Hz (same data as from panel B) or at 3 Hz. Numbers in the bars indicate the number of cells studied from 2 to 12 mice. **P < 0.01 vs. WT. #P < 0.05, ##P < 0.01 vs. Sp−/−.