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. 2014 Aug 7;15:314. doi: 10.1186/1745-6215-15-314

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© Royston and Parmar; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Survival curves in the control and research arms for three hazard ratio patterns. (a) Proportional hazards; (b) increasing treatment effect; (c) decreasing treatment effect.