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. 2014 Aug 9;15(1):271. doi: 10.1186/1471-2105-15-271

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© Zhang et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The results of CoMDP on the GBM1 dataset with k =4 and k =5, and the related p53 and RB pathways. (A) The co-occurrence between the two gene sets {CDKN2A, M G ₁} and {MTAP, CYP27B1} identified by CoMDP with k=4 in the GBM1 dataset. (B) The TP53 and RB tumor suppressor pathways. ARF and INK4A are two alternatively spliced transcripts of CDKN2A. This figure was adapted/extracted according to [31, 32]. (C) The alterative gene regulatory pathway ((a) or (b)) involving CDKN2A, CDK4 and TP53.