Table 2.

10-fold cross validation performance estimation on the dataset S1

	Multi-instance AdaBoost			Multi-instance AdaBoost Novel			Single-instance AdaBoost
	SP	SE	MCC	SP	SE	MCC	SP	SE	MCC
Positive (interaction)	0.7647	0.8387	0.6498	0.7011	0.7871	0.5611	0.6784	0.7484	0.5192
Negative (non-interaction)	0.8214	0.7419	0.6397	0.7574	0.6645	0.5416	0.7194	0.6452	0.5001
[ Acc; MCC ]	[79.03%; 0.6426]			[72.58%; 0.5487]			[69.58%;0.5080]
[ ROC - AUC; PR - AUC ]	[ 0.8210; 0.7743]			[ 0.7846; 0.7521]			[ 0.7655; 0.6971]
F1 score	0.80			0.74			0.71