Table 2.
Clinical characteristics of patients with and without EV71 viremia
| No Viremia (n = 165) | Viremia (n = 59) | pvaluea | |
|---|---|---|---|
| Age (median with range, years) | 2.95 (0–14) | 2.12 (0–15) | 0.05 |
| ≤ 1 years old | 10 (6%) | 14 (24%) | <0.001 |
| > 1 years old | 155 (94%) | 45 (76%) | |
| Gender | 0.43 | ||
| Male | 106 (64%) | 34 (42%) | |
| Female | 59 (36%) | 25 (58%) | |
| Skin rash | 155 (94%) | 58 (98%) | 0.30 |
| Oral ulcer | 162 (98%) | 55 (93%) | 0.08 |
| Fever b | 152 (92%) | 52 (88%) | 0.43 |
| Duration of fever (mean ± SD, days) | 2.99 ± 1.85 | 2.38 ± 1.99 | 0.07 |
| Clinical Severity (Grade 1 to 4) | |||
| Uncomplicated disease | 65 (39%) | 23 (39%) | 0.54d |
| Complicated disease | 100 (61%) | 36 (61%) | |
| Myoclonic jerk or aseptic meningitis | 72 (44%) | 29 (49%) | |
| Severe CNS involvement without cardiopulmonary failure | 17 (10%) | 5 (8%) | |
| Severe CNS involvement with cardiopulmonary failure | 11 (7%) | 2 (3%) | |
| Sample day for PCR test c | |||
| ≤ 3 days | 44 (27%) | 40 (68%) | <0.001 |
| > 3 days | 121 (73%) | 19 (32%) | |
| Viral load c (median with range, log 10 copies/mL) | |||
| ≤ 3 days | 3.68 (0.88 - 6.99) | 0.01 | |
| > 3 days | 3.13 (1.56 – 4.20) | ||
Values expressed as n(%), unless otherwise indicated.
aThe chi-square test was used for categorical variables and the Mann–Whitney test was used for comparison of the viral load.
bFever was defined as any body temperature elevation over 38 degrees Celsius.
cCaterorized as days after disease onset.
dStatistical analysis was performed for the difference between patients with uncomplicated and complicated diseases.