Fig. 5.

Sn is important for production of anti-GBS antibodies during neutropenia. a Decreased total IgM and IgG serum levels after GBS challenge in Sn-deficient mice. Total serum immunoglobulins from GBS-infected mice were measured by isotype specific ELISA (n = 8 for WT and n = 9 for Sn-deficient mice). Mann-Whitney test was used for statistical analysis. Anti-GBS IgM (b) and anti-GBS IgG (c) titers were measured from GBS-infected WT (filled blue circle, n = 8), GBS-infected Sn-deficient (open red circle, n = 9), and uninfected WT mice (filed black circle, n = 6). Difference among groups at each dilution was tested by one-way ANOVA with Tukey’s multiple comparison test. ***P < 0.001. Representative data were shown from two independent experiments