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. 2014 Feb 17;40(5):1154–1163. doi: 10.1093/schbul/sbt154

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© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 4. — Graphical representation of the mendelian randomization approach. The pooled OR (the TT vs CC genotypes) for the effect of the MTHFR C677T polymorphism on schizophrenia risk was 1.16 (95% CI = 1.03–1.31). The OR (the TT vs CC genotypes) for the effect of the MTHFR C677T polymorphism on plasma total homocysteine levels, expressed as 1-SD increase in homocysteine, was 1.14 (95% CI = 0.96–1.33; P = 1.1×10^–29). The effect of plasma total homocysteine on schizophrenia risk by a mendelian randomization analysis was statistically significant, representing the OR of 1.14 (95% CI = 1.03–1.27; P = 1.6×10^–2) for schizophrenia per 1-SD increase in plasma total homocysteine.