Table 3.
Differential Analyte Expression Among HCs and SZ and ARMS Patients
| Analyte | Units | HCsa | SZa | ARMSa | FC, SZ/ARMS | q Value | Group |
|---|---|---|---|---|---|---|---|
| α2M | µg/ml | 3.30 (0.80) | 3.05 (0.80) | 2.80 (0.80) | 0.92/0.85 | 0.023 | 1A |
| ACE | ng/ml | 1.60 (0.75) | 1.35 (0.50) | 1.30 (0.71) | 0.84/0.81 | 0.020 | 2 |
| Adiponectin | ng/ml | 3.60 (2.25) | 3.30 (2.2) | 1.50 (2.1) | 0.92/0.42 | 0.026 | 3 |
| C3 | µg/ml | 1.90 (1.10) | 2.00 (0.88) | 1.70 (0.7) | 1.05/0.89 | 0.037 | 4 |
| EGFR | ng/ml | 0.140 (0.04) | 0.125 (0.052) | 0.120 (0.058) | 0.89/0.86 | 0.027 | 2 |
| Fibrinogen | µg/ml | 0.170 (0.14) | 0.130 (0.22) | 0.064 (0.13) | 0.76/0.38 | 0.020 | 1A |
| IL-6 | pg/ml | 0.920 (0.58) | 1.400 (1.07) | 0.690 (0.77) | 1.52/0.75 | 0.020 | 4 |
| IL-6R | ng/ml | 0.970 (0.43) | 0.855 (0.34) | 0.750 (0.39) | 0.88/0.77 | 0.023 | 1A |
| IL-8 | pg/ml | 21.00 (9.5) | 25.00 (15.0) | 27.00 (9.0) | 1.19/1.29 | 0.022 | 1B |
| MMP3 | ng/ml | 0.160 (0.09) | 0.155 (0.088) | 0.110 (0.059) | 0.97/0.69 | 0.045 | 3 |
| MCP-2/CCL8 | pg/ml | 2.15 (0.50) | 2.90 (1.65) | 3.40 (0.95) | 1.35/1.58 | 0.020 | 1B |
| SCF | pg/ml | 49.00 (17.5) | 44.00 (17.5) | 38.00 (18.5) | 0.90/0.78 | 0.026 | 1A |
| TGFα | pg/ml | 22.00 (7.0) | 20.00 (9.0) | 19.00 (0.15) | 0.91/0.86 | 0.020 | 1A |
| TNFR2 | ng/ml | 0.490 (0.16) | 0.440 (0.23) | 0.380 (0.26) | 0.90/0.78 | 0.041 | 1A |
| Testosterone | ng/ml | 0.085 (0.088) | 0.150 (0.10) | 0.235 (0.068) | 1.76/2.76 | 0.020 | 1B |
Note: Expression changes between healthy controls (HCs), schizophrenia (SZ), and at risk mental status for psychosis (ARMS) were the following: Alpha-2 macroglobulin (α2M), angiotensin converting enzyme (ACE), complement 3 (C3), epidermal growth factor receptor (EGFR), fibrinogen, interleukin-6 (IL-6), interleukin-6 receptor (IL-6R), interleukin-8 (IL-8), matrix metalloproteinase 3 (MMP3), monocyte chemoattractant protein 2 (MCP-2/CCL8), stem cell factor (SCF), transforming growth factor alpha (TGFα), tumor necrosis factor receptor 2 (TNFR2), and testosterone. Fold change (FC) reported as (SZ/HCs)/(ARMS/HCs). Bold values were listed in table 2. Testosterone analyzed only in males. IQR = interquartile range.
aMedian (IQR).