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(A) Receiver-Operator Characteristic (ROC) curves for the predictions provided by the binding motifs alone. (B–D) ROCs for the sets of footprints obtained by DNaseR, Wellington and for the set used in Neph et al. (2012c). (E) Area Under the Curve (AUC) corresponding to the ROCs of (A–D) Wellington scores consistently better than all the other methods. (F) Running times for DNaseR and Wellington on chromosome 19, for different significance thresholds.
