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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Science. 2012 Oct 26;338(6106):482–483. doi: 10.1126/science.1230338

Figure 1. Postsynaptic Elfn1 establishes a low transmitter release probability at pyramidal neuron to somatostatin-containing O-LM interneurons.

Figure 1

In hippocampus somatostatin-containing O-LM and parvalbumin-containing basket cells receive common afferent input from CA1 pyramidal neurons. The postsynaptic expression of the leucine rich repeat protein Elfn1 in O-LM cells acts to set the presynaptic initial transmitter release probability low, ensuring that a train of presynaptic action potentials yields an epoch of short term facilitation of synaptic transmission. In contrast, the absence or Elfn1, or the presence of an as yet undiscovered trans-synaptic protein, endows CA1 pyramidal neuron synapses onto basket cells with a high initial Pr and resulting depressing synapses.