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. 2014 Jul 25;3(8):767–776. doi: 10.1242/bio.20148128

Fig. 6. Cytokines produced during osteoclast differentiation.

Fig. 6.

Human osteoclast precursors were cultured with MCSF (15 or 33 ng/mL) and RANKL (0, 15 or 33 ng/mL) for 24, 48, 72, 144 h and cytokine profiling in conditioned medium was performed using a 47-cytokine multiplex immuno-assay. (A) Time- and [RANKL]-dependence for the production of 12 cytokines during osteoclastogenesis. (B) Cytokine input scores validating that PLSR analysis clustered similar treatments. (C) Cytokine weights (input loadings) for principal components 1 and 2.