Table 3.

Expected diagnostic yield and costs of rapid diagnostic algorithms for a cohort of 10 000 symptomatic individuals evaluated for Tuberculosis.

Algorithm	Cohort	N	Total TB detectedc	% of TB cases detected	Total MDR detected	% of MDR cases detected	Diagnostic cost per patienta	Diagnostic cost per TB case detected	Diagnostic costs: % of total costs	Total diagnostic costs per cohort	Total treatment costs
‘Smear’	Total	10000	1465	66%	9	27%	$17.42	$119	25%b	$174 156	$533 346
	Not TB	7780					$15.83			$123 131	$187 605
	TB	2172	1434	66%			$22.79			$49 507	$315 933
	MDR-TB	48	32	66%	9	27%	$31.62			$1518	$29 808
‘Smear/LF-LAM’	Total	10000	1798	81%	13	33%	$21.34	$119	26%b	$213 339	$599 940
	Not TB	7780					$20.00			$155 588	$177 433
	TB	2172	1759	81%			$25.78			$55 996	$386 085
	MDR-TB	48	39	81%	13	33%	$36.55			$1755	$36 422
‘Xpert’	Total	10000	1931	87%	34	81%	$32.81	$170	33%b	$328 143	$655 047
	Not TB	7780					$31.21			$242 850	$158 000
	TB	2172	1890	87%			$37.79			$82 077	$423 993
	MDR-TB	48	42	87%	34	81%	$67.01			$3216	$73 054
‘Xpert/LF-LAM’	Total	10000	2065	93%	37	82%	$36.68	$177	35%b	$366 830	$679 843
	Not TB	7780					$35.40			$275 398	$154 368
	TB	2172	2020	93%			$40.55			$88 072	$450 870
	MDR-TB	48	45	93%	37	82%	$70.01			$3360	$74 605

^aInclusive of costs associated with clinical evaluation, chest radiograph, CD4⁺ testing, and specimen transport in addition to TB diagnostic testing

^bWhen HIV/ART care is included in total costs, diagnostic costs as a percentage of total costs are 0.006, 0.006%, 0.007, and 0.008% for ‘Smear’, ‘Smear/LF-LAM’, ‘Xpert’, ‘Xpert/LF-LAM’, respectively.

^cIncludes clinical diagnosis and empiric TB treatment, and is inclusive of repeat evaluations.