Figure 1. Frequency of promoter gene methylation in resected stage I-IIIA NSCLCs.
The percentage of tumors with methylated promoter regions of ten tumor suppressor genes is depicted. Genes whose promoter regions were found to be methylated in at least 50% of samples tested include CDH13 (87%), WIF1 (64%), DAPK (62%), APC (57%), and RASSF1A (50%). ADAMTS8 (36%), CDKN2A (31%), MGMT (8%), and GSTP1 (5%) were less commonly methylated. SOCS3 was not found to be methylated in any samples.