Table 2. Association between tumor suppressor gene promoter methylation and survival.
Median recurrence-free survival (RFS) and overall survival (OS) for patients with both methylated and unmethylated promoters of 10 tumor suppressor genes are shown. SOCS3 was not found to be methylated in any samples and could not be analyzed in relation to RFS or OS. NR - not reached.
| Gene | Methylation Results | Median RFS |
p-value | Median OS |
p- value |
|---|---|---|---|---|---|
| CDH13 | Methylated (87%, n=93) Unmethylated (13%, n=14) |
4.5 mo 2.7 mo |
p=0.43 | 6.2 mo 4.4 mo |
p=0.59 |
| WIF1 | Methylated (64%, n=69) Unmethylated (36%, n=38) |
4.5 mo 3.9 mo |
p=0.49 | 6.2 mo NR |
p=0.57 |
| DAPK1 | Methylated (62%, n=66) Unmethylated (38%, n=41) |
4.9 mo 2.8 mo |
p=0.09 | NR 4.2 mo |
p=0.03 |
| APC | Methylated (57%, n=62) Unmethylated (43%, n=45) |
3.5 mo 5.0 mo |
p=0.56 | 4.3 mo NR |
p=0.07 |
| RASSF1 | Methylated (50%, n=54) Unmethylated (50%, n=53) |
4.0 mo 4.5 mo |
p=0.86 | 5.3 mo NR |
p=0.67 |
| ADAMTS8 | Methylated (36%, n=38) Unmethylated (64%, n=69) |
5.0 mo 3.8 mo |
p=0.49 | 6.2 mo 5.3 mo |
p=0.71 |
| CDKN2A | Methylated (31%, n=33) Unmethylated (68%, n=74) |
4.9 mo 3.9 mo |
p=0.60 | 6.1 mo 6.2 mo |
p=0.72 |
| MGMT | Methylated (8%, n=9) Unmethylated (92%, n=98) |
3.4 mo 4.3 mo |
p=0.92 | 4.2 mo 6.2 mo |
p=0.65 |
| GSTP1 | Methylated (5%, n=6) Unmethylated (95%, n=101) |
3.6 mo 4.5 mo |
p=0.95 | 4.2 mo 6.2 mo |
P=0.81 |
| SOCS3 | Methylated (0%, n=0) Unmethylated (100%, n=107) |
- - |
- | - - |
- |