Table 2.
Associations between baseline proteinuria (urine protein/creatinine >200 mg/g at the initial neurocognitive assessment) and prevalent and incident neurocognitive impairment, estimated as odds ratios and 95 percent confidence intervals (CI) adjusting for diabetes and other baseline and longitudinal risk factors.
| Prevalent NCI (Baseline)1 | Incident NCI (Longitudinall2 | |||
|---|---|---|---|---|
| N=1,972 | N=1,372 | |||
| Variables | Odds Ratio (95% CI) | P-value | Odds Ratio (95% CI) | P-value |
| UP/Cr at baseline (≥200 vs <200 mg/g) | 1.41 (1.08, 1.85) | 0.01 | 1.39 (1.01, 1.93) | 0.046 |
| eGFR at baseline (per 10 mL/min/1.73m2 increase) | 1.08 (1.01,1.16) | 0.02 | - | |
| Age at baseline (per 10 year increase) | 1.00 (0.87,1.14) | >0.90 | 1.22 (1.03, 1.45) | 0.02 |
| Sex (Female vs. Male) | 1.55 (1.18,2.05) | 0.002 | 1.39 (0.99, 1.95) | 0.05 |
| Race/Ethnicity | ||||
| White vs. Black | 1.02 (0.78, 1.35) | 0.87 | 1.09 (0.76, 1.55) | 0.65 |
| Hispanic vs. Black | 2.67 (2,00, 3.55) | <0.001 | 2.70 (1.82, 4.00) | <0.001 |
| Years of Education at baseline (per 1 year increase) | 0.95 (0.92, 0.98) | 0.004 | 1.01 (0.95,1.06) | 0.85 |
| Grade μ3 Anemia at baseline | 4.89 (0.85, 28.22) | 0.08 | - | |
| Grade μ3 Thrombocytopenia at follow up (time-updated) | - | 7.66 (1.85, 31.75) | 0.005 | |
| Pharmacologically-treated Diabetes at baseline | 1.89 (1.14, 3.13) | 0.01 | - | |
. Based on logistic regression; model also included: previous or current injection drug use history and ART- experience at entry to ALLRT; baseline CD4 (>200 vs ≤ 200 cells/μL).
.Based on logistic Generalized Estimating Equations regression modelling; model also included: previous or current injection drug use history and ART- experience at entry to ALLRT, hepatitis B and hepatitis C status, baseline HIV-RNA ( > 200 vs ≤ 200 copies/mL), HIV-RNA copies at follow-up and time-updated diagnosis of hypertension.