Figure 1.

Representative post-mortem histopathology findings in H & E stained brain sections from (i) wild-type and (ii) IFN-γ^−/− C57BL/6 mice on day 6 post-inoculation with 1 × 10⁶ PbA-PRBC. As no difference was evident between uninfected mice and infected IFN-γ^−/− mice, only the latter are shown. (A) Olfactory bulb; (B) Meningeal vessel; (C) Cerebellum. The brains of PbA-infected w/type mice showed hemorrhage and leukocyte adhesion to the cerebral vasculature (arrows), whereas no pathological findings were evident in any IFN-γ^−/− mouse. In this and later Figures (where appropriate) the work was carried out according to national and State legislation on animal experimentation, with approval from the University of Sydney Animal Ethics Committee.