TABLE 1.
Baseline demographics and clinical characteristics of depressed, cocaine-dependent patients (N = 130) randomized to venlafaxine or placebo in a double-blind, placebo-controlled clinical trial of venlafaxine
| Variable | PBO (n = 66) | Ven (n = 64) |
|---|---|---|
| Age (years) | 38 (8) | 37 (8) |
| Male | 73% (48/66) | 72% (46/64) |
| Race | ||
| African American | 29% (19/66) | 23% (14/62) |
| Hispanic | 29% (19/66) | 24% (15/62) |
| Caucasian | 33% (22/66) | 45% (28/62) |
| Other | 9% (6/66) | 8% (5/62) |
| Education (% post HS) | 48% (30/63) | 60% (37/62) |
| Marital status | ||
| Not married | 48% (31/64) | 53% (33/62) |
| Married | 31% (20/64) | 24% (15/62) |
| Divorced/separated | 20% (13/64) | 23% (14/62) |
| Employment | ||
| Full-time | 68% (41/60) | 79% (46/58) |
| Part-time | 8% (5/60) | 12% (7/58) |
| Unemployed | 23% (14/60) | 9% (5/58) |
| Income | ||
| <25 K | 44% (24/55) | 40% (21/52) |
| 25–50 K | 49% (27/55) | 39% (20/52) |
| >50 K | 7% (4/55) | 21% (11/52) |
| Ham-D 21: total score | 16.39 (4.99) | 15.70 (4.77) |
| CGI Dep: severity score | 4.49 (.82) | 4.42 (.90) |
| Type of depression | ||
| Primary | 42% (27/65) | 40% (25/63) |
| Secondary | 40% (26/65) | 38% (24/63) |
| Diagnosis of dysthymia | 18% (12/65) | 22% (14/63) |
| Diagnosis of dysthymia + major depression | 9% (6/65) | 10% (6/63) |
| CGI Coc: severity score | 4.09 (1.21)* | 3.53 (1.52)* |
| Days/week: using cocaine | 1.97 (1.98) | 1.57 (1.80) |
| Days/week: craving cocaine | 4.61 (2.27) | 3.98 (2.50) |
| Diagnosis of alcohol dependence | 21% (14/66) | 23% (15/64) |
| Diagnosis of cannabis dependence | 14% (9/66) | 11% (7/64) |
*
There were no significant differences between placebo and venlafaxine groups, except for CGI cocaine severity score (t = 2.3, p = .02).