Fig. 4. Effect of mannose or GlcNAc onto mouse MBL-A and ficolin-A-mediated inhibition of IL-6 production on mBMMCs. LPS (200 ng/ml, smooth type from E. coli serotype O4) was pre-incubated with mouse MBL-A (1,000 μg/ml) and ficolin-A (1,000 ng/ml) in the presence of mannose (0.1 M) or GlcNAc (0.1 M) prior to stimulation of mBMMCs. mIL-6 levels were measured in culture supernatants. Data are represented as means ± S.D. from triplicate experiments. Asterisk indicates the statistical significance versus controls: *P ＜ 0.01.