Table .5.
Sensitivity of influenza viruses to HAI by normal guinea pig sera.
| Virus Tested | Origin of Gene | HAI Titer | Sensitivity to Inhibitors | |||
|---|---|---|---|---|---|---|
| Code | Strain Designation (Subtype) | Type/Subtype | HA | NA | ||
| Influenza A Viruses | ||||||
| MDV1 | A-MDV | H2N2 | MDV | MDV | < 10 | Resistant4 |
| WT2 | A/California/07/04 | H3N2 | WT | WT | 2560 | Sensitive5 |
| R13 | A/California/07/04 × MDV | H3N2 | WT | MDV | 320 | Sensitive (<)7 |
| R2 | A/California/07/04 × MDV | H3N2 | WT | WT | 2560 | Sensitive (=)7 |
| WT | NIBRG-23 | H5N1 | WT | WT | 5120 | Sensitive |
| R3 | NIBRG-23 × MDV | H5N2 | WT | MDV | 640 | Sensitive (<) |
| R4 | NIBRG-23 × MDV | H5N2 | WT | MDV | 640 | Sensitive (<) |
| R5 | NIBRG-23 × MDV | H5N2 | WT | MDV | 640 | Sensitive (<) |
| WT | INDO/05 | H5N1 | WT | WT | 10 | Resistant |
| R6 | INDO/05 × MDV | H5N2 | WT | MDV | 10 | Resistant (=) |
| R7 | INDO/05 × MDV | H5N2 | WT | MDV | 10 | Resistant (=) |
| WT | VN1203 | H5N1 | WT | WT | < 10 | Resistant |
| R8 | VN1203 × MDV | H5N2 | WT | MDV | < 10 | Resistant (=) |
| R9 | VN1203 × MDV | H5N2 | WT | MDV | < 10 | Resistant (=) |
| R106 | A/Vietnam/1203/2004 × MDV | H5N2 | WT | WT | < 10 | Resistant (=) |
| Influenza B Viruses | ||||||
| MDV | B-MDV | B | MDV | MDV | < 10 | Resistant |
| WT | B/Harbin/07/94 | B | WT | WT | 10240 | Sensitive |
| R11 | B/Harbin/07/94 × MDV | B | WT | MDV | 2560 | Sensitive (<) |
| WT | B/Texas/26/08 | B | WT | WT | < 10 | Resistant |
| R12 | B/Texas/26/08 × MDV | B | WT | MDV | < 10 | Resistant (=) |
| R13 | B/Texas/26/08 × MDV | B | WT | WT | < 10 | Resistant (=) |
| WT | B/Wisconsin/1/10 | B | WT | WT | 5120 | Sensitive |
| R14 | B/Wisconsin/1/10 × MDV | B | WT | MDV | 320 | Sensitive (<) |
| R15 | B/Wisconsin/1/10 × MDV | B | WT | WT | 5120 | Sensitive (=) |
| R16 | B/Wisconsin/1/10 × MDV | B | WT | WT | 5120 | Sensitive (=) |
| WT | B/Bangladesh/1994/10 | B | WT | WT | 5120 | Sensitive |
| R17 | B/Bangladesh/1994/10 × MDV | B | WT | MDV | 640 | Sensitive (<) |
| WT | B/Texas/06/11 | B | WT | WT | 640 | Sensitive |
| R18 | B/Texas/06/11 × MDV | B | WT | MDV | 80 | Sensitive (<) |
| R19 | B/Texas/06/11 × MDV | B | WT | WT | 640 | Sensitive (=) |
1MDV for LAIV: A/Leningrad/134/17/57 (H2N2) (A-MDV) or B/USSR/60/69 (B-MDV). 2WT virus or PR8-based virus inheriting HA and NA from WT virus. 3Reassortants of WT virus with MDV; the reassortants inherited HA from WT virus, and NA from WT virus (genomic composition 6:2) or MDV (genomic composition 7:1). 4Virus resistant to non-specific serum heat-stable inhibitors. 5Virus sensitive to non-specific serum heat-stable inhibitors. 66:2 R10 reassortant virus generated by plasmid-based reverse genetics as described in [14]. 7Sensitivity of reassortant virus to non-specific serum heat-stable inhibitors compared to WT parental virus; p < 0.0001).