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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Stroke. 2011 Sep 29;42(12):3415–3420. doi: 10.1161/STROKEAHA.111.627331

Table 3.

Likelihood for a Good Outcome at Given Time Points Based on Initial Plasma α-MSH or Cortisol

Variable Model α-MSH
ACTH
Cortisol
IL-6
mRS ≤3 P mRS ≤3 P mRS ≤3 P mRS ≤3 P
1 mo, N=102 Unadjusted 1.355 (0.938–1.957) 0.105 0.852 (0.676–1.075) 0.176 0.169 (0.075–0.381) <0.001 0.583 (0.389–0.874) 0.009
NIHSS 1.031 (0.694–1.531) NS 0.921 (0.688–1.232) NS 0.394 (0.158–0.986) 0.047 0.896 (0.633–1,269) NS
NIHSS+age 1.000 (0.667–1.499) NS 0.931 (0.698–1.241) NS 0.389 (0.153–0.988) 0.047 0.915 (0.643–1.302) NS
NIHSS+age+infection 0.991 (0.657–1.494) NS 0.940 (0.693–1.274) NS 0.392 (0.154–0.998) 0.049 0.940 (0.661–1.337) NS
3 mo, N=100 Unadjusted 2.147 (1.159–3.978) 0.015 0.840 (0.659–1.070) 0.157 0.299 (0.154–0.581) <0.001 0.556 (0.375–0.825) 0.004
NIHSS 1.639 (0.883–3.043) 0.118 0.880 (0.657–1.180) NS 0.657 (0.307–1.405) NS 0.755 (0.518–1.102) 0.145
NIHSS+age 1.568 (0.844–2.911) 0.154 0.896 (0.678–1.183) NS 0.664 (0.300–1.467) NS 0.752 (0.503–1.123) 0.163
NIHSS+age+infection 1.688 (0.859–3.319) 0.129 0.923 (0.682–1.248) NS 0.721 (0.311–1.669) NS 0.792 (0.530–1.183) NS
6 mo, N=97 Unadjusted 5.212 (1.614–16.834) 0.006 0.736 (0.560–0.969) 0.029 0.368 (0.178–0.759) 0.007 0.877 (0.738–1.042) 0.136
NIHSS 4.219 (1.225–14.530) 0.023 0.741 (0.533–1.032) 0.076 0.724 (0.300–1.747) NS 1.033 (0.855–1.248) NS
NIHSS+age 4.236 (1.191–15.063) 0.026 0.729 (0.534–0.996) 0.047 0.662 (0.254–1.727) NS 1.030 (0.852–1.246) NS
NIHSS+age+infection 5.763 (1.350–24.591) 0.018 0.737 (0.537–1.011) 0.059 0.677 (0.257–1.784) NS 1.050 (0.863–1.278) NS
12 mo, N=96 Unadjusted 4.444 (1.322–14.943) 0.016 0.874 (0.657–1.163) NS 0.464 (0.215–1.000) 0.050 0.873 (0.734–1.039) 0.125
NIHSS 3.551 (1.034–12.201) 0.044 0.922 (0.683–1.245) NS 0.937 (0.355–2.473) NS 1.006 (0.831–1.218) NS
NIHSS+age 3.502 (0.991–12.370) 0.052 0.920 (0.625–1.354) NS 0.859 (0.288–2.563) NS 0.998 (0.820–1.215) NS
NIHSS+age+infection 4.612 (1.087–19.572) 0.038 0.933 (0.630–1.381) NS 0.933 (0.294–2.955) NS 1.012 (0.826–1.240) NS

Data are presented as the odds ratio (95% CI) per 10-pg/mL increase in plasma α-MSH, ACTH, and IL-6 concentrations or 10-μg/dL increase in cortisol concentration.

Data show the highest plasma α-MSH, ACTH, cortisol, or IL-6 within the first 72 h after stroke.

MSH indicates melanocyte stimulating hormone; ACTH, adrenocorticotrophic hormone; IL, interleukin; NIHSS, National Institutes of Health Stroke Scale; NS, not significant (P≥0.200); CI, confidence interval.