Figure 6.

Transgenic mice expressing COXIV zipcode manifest behavioral deficits. (A) Transgenic mice expressing the mCherry+3′UTR [38bp] show a significant increased latency to enter the anxiogenic open-arm in an elevated plus-maze test as compared to non-transgenic control littermates. (B) A consistent decrease in exploration of the anxiogenic center region of a novel open-field was observed in transgenic mice as compared to control littermates; however the differences did not reach statistical significance. (C) Light-dark box test showed that transgenic mice decreased latency to first entry into the dark-compartment as compared to control littermates, when the mice were placed in the light-compartment at the start of the test. (D) Transgenic mice expressing COXIV zipcode show statistically higher immobility in forced swim test as compared to non-transgenic littermates. Data are shown as mean values ± SEM. Number in parentheses: number of animals. One-way ANOVA,*, p<0.05