Figure 7.

The behavior of transgenic and non-transgenic control mice were similar in measures of learning and memory. (A) In Y-maze spontaneous alternation task, the transgenic mice and the non-transgenic littermates showed similar alternation percentages. (B) Transgenic and control mice were subjected to cued-fear conditioning. Freezing was similar in both groups during conditioning. No significant difference was observed in freezing behavior between transgenic and control littermates after presentation of the tone during the testing phase 24 h after training. (C) Rotarod test was conducted to measure motor coordination and learning. Both transgenic and non-transgenic littermates exhibited similar motor coordination, as well as motor learning as evidenced by an increased latency to fall across trials.