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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Proceedings (IEEE Int Conf Bioinformatics Biomed). 2013:349–355. doi: 10.1109/BIBM.2013.6732517

Table I. Examples of disease topics (3 out of 50) and drugs learned from the 2010 Medline corpus.

Topic 17 Topic 30 Topic 32

DISEASE PROB. DISEASE PROB. DISEASE PROB.
kidney disease 0.0906 diabetes 0.3285 depression 0.2310
disease 0.0643 diabetes mellitus 0.0661 relapse 0.0447
vitamin d deficiency 0.0411 hyperglycemia 0.0605 major depressive disorder 0.0385
death 0.0282 type 2 diabetes mellitus 0.0404 blind 0.0362
stone 0.0264 hypoglycemia 0.0380 major depression 0.0333
end-stage renal disease 0.0240 diabetic nephropathy 0.0230 mental disorders 0.0271
renal failure 0.0220 proteinuria 0.0210 stress 0.0264
secondary hyperparathyroidism 0.0220 hypokalemia 0.0173 suicide 0.0256
hypocalcemia 0.0219 hyperglycaemia 0.0160 drug abuse 0.0234
hyperparathyroidism 0.0211 type 1 diabetes mellitus 0.0149 anxiety disorders 0.0229

DRUG PROB. DRUG PROB. DRUG PROB.

Cinacalcet 0.0626 Streptozocin 0.0730 Fluoxetine 0.0618
Preotact 0.0548 Glucagon recombinant 0.0458 Escitalopram 0.0589
Sevelamer 0.0473 Exenatide 0.0434 Paroxetine 0.0562
Calcium carbonate 0.0409 Glyburide 0.0419 Citalopram 0.0550
Calcitriol 0.0387 Insulin Glargine 0.0404 Agomelatine 0.0519
Tamsulosin 0.0327 Insulin Aspart 0.0394 Sertraline 0.0509
Paricalcitol 0.0270 Saxagliptin 0.0326 Cocaine 0.0502
Cholecalciferol 0.0236 Sitagliptin 0.0325 Desvenlafaxine 0.0492
Ergocalciferol 0.0221 Glimepiride 0.0300 Nicotine 0.0461
Iohexol 0.0195 Acarbose 0.0297 Venlafaxine 0.0434