Skip to main content
. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Prostate. 2012 Feb 1;72(10):1045–1051. doi: 10.1002/pros.22490

Figure 4.

Figure 4

Hoxb13-rtTA-26 strain demonstrates rapid responder extinction kinetics following Dox-withdrawal. Double transgenic mice were treated with Dox for 24 hr followed by replacement with water for indicated period of time. Ventral prostate dissected from treated mice was analyzed by qRT-PCR (top panel). Complete loss of responder gene transcript was seen within 48 hr. Northern blot analyses of mRNA obtained from tissues of treated mice demonstrating loss of rtTA transcript at longer time points. Probes used were specific to H2BGFP or β-actin bottom panel).