. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Am J Gastroenterol. 2014 Mar 18;109(5):695–704. doi: 10.1038/ajg.2014.32

Table 4.

Multivariable analysis of factors associated with fatty liver among the entire cohort and among the HIV-infected men only

	Entire cohort (n=652)^a		HIV uninfected (n=230)^a		HIV infected (n=421)^a
	OR	P value	OR	P value	OR	P value
HIV	0.44 (0.26, 0.74)	0.002
Abdominal VAT (per 10 cm²)	1.08 (1.04, 1.11)	< 0.001	1.08 (1.03, 1.14)	0.002	1.07 (1.03, 1.12)	< 0.001
PNPLA3 (rs738409) non-CC	2.03 (1.24, 3.33)	0.005	1.14 (0.51, 2.54)	0.746	3.30 (1.66, 6.57)	0.001
ALT > 40 U/l	2.99 (1.65, 5.42)	< 0.001	7.21 (2.13, 24.41)	0.002	2.54 (1.20, 5.36)	0.015
HOMA-IR≥4.9^b	2.50 (1.44, 4.36)	0.001	2.27 (0.89, 5.76)	0.084	2.54 (1.24, 5.19)	0.011
Race (ref=white)
Black	0.49 (0.24, 1.03)	0.059	0.48 (0.13, 1.74)	0.266	0.54 (0.21, 1.39)	0.200
Other	0.95 (0.41, 2.24)	0.915	1.11 (0.27, 4.59)	0.883	0.61 (0.19, 2.02)	0.423
HCV	0.55 (0.17, 1.82)	0.329	0.40 (0.03, 5.95)	0.503	0.54 (0.14, 2.18)	0.394
Cumulative dideoxynucleoside (per 5 year exposure)					1.44 (1.06, 1.97)	0.021

ALT, alanine aminotransferase; HOMA-IR, homeostatic model assessment of insulin resistance; VAT, visceral adipose tissue.

Also adjusted for age and MACS site.

75% Percentile for HOMA in the cohort.