Table 4.
General biomarkers in the blood of Japanese male subjects.
| REFERENCE VALUE | WEEK 1 (DAY 5) |
WEEK 2 (DAY 12) |
WEEK 3 (DAY 19) |
WEEK 4 (DAY 26) |
|
|---|---|---|---|---|---|
| Erythrocyte count, ×104/μL | 430–570 | 542 ± 17 | 529 ± 18 | 531 ± 20 | 525 ± 18 |
| Leukocyte count, μL | 3300–9000 | 5040 ± 1146 | 5150 ± 1339 | 5120 ± 1155 | 5210 ± 1333 |
| Hemoglobin, g/dL | 13.5–17.5 | 16.3 ± 0.5 | 15.8 ± 0.4 | 15.7 ± 0.5 | 15.7 ± 0.3 |
| Hematocrit, % | 39.7–52.4 | 48.7 ± 2.0 | 47.6 ± 1.9 | 47.1 ± 1.9 | 47.4 ± 1.8 |
| MCV, fL | 85–102 | 90.0 ± 3.7 | 90.0 ± 3.4 | 88.8 ± 3.4 | 90.5 ± 3.7 |
| MCH, pg | 28.0–34.0 | 30.1 ± 1.0 | 30.0 ± 0.8 | 29.5 ± 0.9 | 29.9 ± 0.8 |
| MCHC, % | 30.2–35.1 | 33.5 ± 0.7 | 33.3 ± 0.7 | 33.3 ± 0.5 | 33.1 ± 0.7 |
| AST, U/L | 10–40 | 16.4 ± 4.6 | 20.0 ± 6.1 | 22.6 ± 5.3 | 21.1 ± 6.7 |
| ALT, U/L | 5–45 | 17.6 ± 6.0 | 21.9 ± 7.4 | 19.3 ± 8.4 | 21.9 ± 5.5 |
| γ-GTP, U/L | >80 | 21.6 ± 12.9 | 21.1 ± 13.0 | 21.8 ± 14.1 | 22.2 ± 14.4 |
| HDL-Cho, mg/dL | 40–70 | 50 ± 6 | 49 ± 8 | 48 ± 6 | 50 ± 8 |
| Total-Cho, mg/dL | 120–219 | 175 ± 31 | 169 ± 22 | 174 ± 22 | 180 ± 27 |
| Triglyceride, mg/dL | 30–149 | 96 ± 60 | 93 ± 58 | 55.4 ± 24.8 | 54.9 ± 17.3 |
| Total lipid, mg/dL | 400–800 | 513 ± 74 | 493 ± 44 | 543 ± 106 | 539 ± 91 |
| Blood glucose, mg/dL | 70–109 | 86 ± 5 | 85 ± 5 | 86 ± 5 | 86 ± 5 |
| Total protein, mg/dL | 6.7–8.3 | 7.9 ± 0.4 | 7.5 ± 0.3 | 7.5 ± 0.4 | 7.6 ± 0.4 |
| Albumin, mg/dL | 3.8–5.3 | 5.2 ± 0.2 | 5.1 ± 0.2 | 5.0 ± 0.2 | 5.0 ± 0.2 |
| Albumin/Globurin | 1.1–2.0 | 1.9 ± 0.3 | 2.1 ± 0.3 | 2.1 ± 0.2 | 2.0 ± 0.3 |
| Creatinine, mg/dL | 0.61–1.04 | 0.91 ± 0.06 | 0.85 ± 0.06 | 0.84 ± 0.08 | 0.85 ± 0.09 |
| Uric acid, mg/dL | >7.0 | 6.1 ± 1.1 | 6.0 ± 1.0 | 6.0 ± 1.1 | 5.9 ± 1.0 |
| Homocysteine, nmol/mL | 3.7–13.5 | 7.1 ± 0.8 | 7.1 ± 0.9 | 6.6 ± 0.8 | 6.5 ± 0.8 |
| Total bilirubin, mg/dL | 0.–1.1 | 1.1 ± 0.4 | 1.0 ± 0.3 | 0.9 ± 0.3 | 1.1 ± 0.3 |
| PIVKA-II, μg/mL | >1 | >1 | >1 | >1 | >1 |
Notes:
1
Values are means ± SD for the 10 subjects. Nonparametric Friedman test for repeated measures following Dunn’s post-test was used to analyze statistical differences; no significant differences were observed at all.
Abbreviations: MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.