Table 3.
Meta-analysis PheWAS results for rs8050136 with and without adjustment for average BMI.
| Phenotype | Cases | Not adjusted for BMI | Adjusted for BMI | ||
|---|---|---|---|---|---|
| p† | OR (95% CI) | p† | OR (95% CI) | ||
| Overweight | 3943 | 1.38 × 10−8 | 1.17 (1.11–1.24) | 0.185 | 1.05 (0.98–1.12) |
| Obesity | 1662 | 2.10 × 10−9 | 1.25 (1.16–1.35) | 0.017 | 1.11 (1.02–1.22) |
| Morbid obesity | 756 | 1.07 × 10−7 | 1.34 (1.20–1.48) | 0.016 | 1.17 (1.03–1.33) |
| Type 2 diabetes | 3936 | 2.34 × 10−6 | 1.14 (1.08–1.21) | 4.56 × 10−4 | 1.09 (1.03–1.15) |
| Sleep apnea | 2335 | 3.33 × 10−5 | 1.14 (1.07–1.22) | 0.040 | 1.07 (1.00–1.15) |
| Cystic mastopathy | 967 | 2.00 × 10−4 | 0.82 (0.74–0.91) | 4.75 × 10−4 | 0.84 (0.75–0.92) |
| Chronic Nonalcoholic Liver disease | 684 | 2.22 × 10−4 | 1.23 (1.10–1.37) | 1.86 × 10−3 | 1.19 (1.07–1.33) |
| Chronic Ulcer of Leg or Foot | 768 | 8.31 × 10−4 | 1.19 (1.08–1.32) | 2.55 × 10−3 | 1.17 (1.06–1.30) |
| Acute Renal Failure | 2047 | 1.12 × 10−3 | 1.12 (1.05–1.20) | 3.74 × 10−3 | 1.11 (1.03–1.19) |
| Staphylococcus infections | 723 | 2.44 × 10−3 | 1.18 (1.06–1.31) | 5.76 × 10−3 | 1.16 (1.04–1.29) |
| Superficial cellulitis and abscess | 2861 | 5.65 × 10−3 | 1.09 (1.02–1.15) | 0.039 | 1.06 (1.00–1.13) |
| Streptococcus infection | 428 | 4.26 × 10−3 | 1.21 (1.05–1.39) | 6.56 × 10−3 | 1.21 (1.05–1.39) |
| Osteomyelitis | 352 | 6.15 × 10−3 | 1.23 (1.06–1.43) | 0.011 | 1.21 (1.04–1.41) |
| All gram positive infections | 1095 | 6.21 × 10−4 | 1.16 (1.07–1.27) | 1.3 × 10−3 | 1.15 (1.06–1.26) |
| Joint effusions | 387 | 2.35 × 10−3 | 1.25 (1.08–1.44) | 6.90 × 10−3 | 1.22 (1.06–1.41) |
This table includes all phenotypes with p-value less than 1.00 × 10−4 prior to BMI adjustment. The Bonferroni alpha = 0.05 equates to a p-value of 4.95 × 10−5, and an FDR of q = 0.05 gives a p-value of 2.48 × 10−4. OR, Odds ratio; CI, confidence interval. The ICD-9 codes that are associated with each phenotype can be found at the PheWAS catalog located online at http://phewas.mc.vanderbilt.edu/.
†
Values are not corrected for multiple testing.