. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Curr Opin Pulm Med. 2013 Sep;19(5):516–523. doi: 10.1097/MCP.0b013e3283642ad0

Table 1. Treatment recommendations for sarcoidosis.

	First line	Second line	Third line
Pulmonary	Corticosteroids	MTX AZA	TNFi RTX VIP? Antioxidants?
Extrapulmonary
Ocular	Corticosteroids	MTX AZA? LEF	TNFi
Cutaneous	Corticosteroids	HCQ LEF MTX? AZA?	Apremilast?
Lymph node	Corticosteroids	MTX LEF? AZA?	TNFi?
Musculoskeletal	Corticosteroids NSAID	MTX HCQ AZA?	TNFi
Neurosarcoidosis	Corticosteroids	MTX AZA CYC MMF?	TNFi?
Cardiac	Corticosteroids	MTX AZA CYC LEF?	TNFi?
Renal	Corticosteroids	AZA HCQ TNFi?
Small-fiber neuropathy		TNFi IVIG ARA 290
Sarcoidosis-associated fatigue	Treat sarcoidosis activity Rehabilitation	Methylphenidate Armodafinil CBT	TNFi?

AZA, azathioprine; CBT, cognitive-behavioral therapy; CYC, cyclophosphamide; HCQ, hydroxychloroquine; IVIG, intravenous immunoglobulins; LEF, leflunomide; MMF, mycophenolate mofetil; MTX, methotrexate; RTX, rituximab; TNFi, tumor necrosis factor alpha inhibitors; VIP, vasoactive intestinal peptide.