. 2014 Aug 8;9:3791–3800. doi: 10.2147/IJN.S65601

Table 2.

Schirmer tear test results in rabbits (mm)

Days	Untreated	Restasis^®-treated	EPCS-treated¹	S100-treated²
0	13.08±1.56	15.08±4.16	14.50±0.70	14.33±0.68
P₁		0.31	0.082	0.116
P₂			0.748	0.68
P₃				0.686
P₄				0.498
3	9.75±2.31	8.46±3.77	9.50±2.36	8.66±2.40
P₁		0.064	0.468	0.348
P₂			0.163	0.45
P₃				0.714
P₄				0.823
5	9.0±2.16	11.25±1.21	13.16±2.38	13.83±2.25
P₁		0.025^*	0.015^*	0.006^*
P₂			0.119	0.039^*
P₃				0.628
P₄				0.002^*
8	8.75±0.97	12.00±3.40	14.08±3.82	14.50±3.61
P₁		0.071	0.017^*	0.009^*
P₂			0.342	0.246
P₃				0.85
P₄				0.020^*
10	8.10±2.13	11.75±1.54	14.58±1.11	14.91±2.20
P₁		0.007^*	0.000^*	0.000^*
P₂			0.005^*	0.018^*
P₃				0.749
P₄				0.000^*

Notes: Each group consists of three rabbits with a total number of six eyes. Data are expressed as mean ± standard deviation.

Significant difference when P<0.05.

SCF-EPCS liposomes.

SCF-S100 liposomes. P₁: Restasis^®-treated, EPCS-treated, and S100-treated groups are compared with the untreated group. P₂: EPCS-treated and S100-treated groups are compared with the Restasis^®-treated group. P₃: S100-treated group is compared with the EPCS-treated group. P₄: one-way ANOVA between the four groups. Restasis^®, Allergan Inc., Irvine, CA, USA.

Abbreviations: ANOVA, analysis of variance; SCF-S100, supercritical fluid-mediated liposomes prepared using Lipoid S100; SCF, supercritical fluid; S100, phosphatidylcholine from soybean lecithin; EPCS, phosphatidylcholine from egg lecithin; SCF-EPCS, supercritical fluid-mediated liposomes prepared using Lipoid EPCS.