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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Thorac Oncol. 2014 Sep;9(9):1264–1271. doi: 10.1097/JTO.0000000000000262

Table 3.

Results from Cox proportional hazards regression models: joint rs1045642-rs2235046-rs1128503 haplotype (additive genetic model) association with overall survival (white race, stage III-IV, chemotherapy administered, N=160)

Haplotype Freq Unadjusted Adjusted[1]


HR 95% CI p-value HR 95% CI p-value
GCG 0.46 REF REF
ATA 0.39 1.54 1.14-2.09 0.006 1.46 1.05-2.03 0.023
ACG 0.11 1.22 0.80-1.86 0.353 1.18 0.77-1.82 0.446
GTA 0.04 2.42 1.21-4.83 0.012 2.19 1.06-4.52 0.035

Abbreviations: Freq estimated haplotype frequency, HR hazard ratio (per allele), CI confidence interval

1

Adjusted for year of diagnosis (1990-1999 / 2000-2008), sex (men / women), age at diagnosis (<55 / 55-64 / 65-69 / 70-74 / 75+), pack years (<35 / 35-49 / 50-74 / 75+), and stage (III / IV)