Table 2.
Histomorphological and immunohistochemical profile of SFTP
| |
All (n = 42) |
Malignant (n = 18) |
Benign (n = 24) |
p
-value* |
|---|---|---|---|---|
| Histomorphology | ||||
| Atypical localization |
2 (4.8) |
1 (5.6) |
1 (4.2) |
ns |
| Tumor size [cm] |
6.2 (4.8-14.1) |
|
|
|
| Tumor size > 10 cm |
19 (45.2) |
12 (66.7) |
7 (29.2) |
0.002 |
| Sessile tumor |
11 (26.2) |
7 (38.9) |
4 (16.7) |
ns |
| Necrosis |
19 |
11 (61.1) |
7 (29.2) |
0.024 |
| Nr of mitoses per 10 HPF |
4.1 (1.0-7.25) |
|
|
|
| > 10 mitoses per 10 HPF |
14 (33.3) |
13 (72.2) |
0 (0) |
0.022 |
| Pleomorphism |
8 (19.0) |
6 (33.3) |
2 (8.3) |
0.03 |
|
Immunohistochemistry |
|
|
|
|
| Ki-67 (proliferation rate)** |
5 (1–7) |
13.3 |
3.2 |
0.01 |
| Ki-67 > 12%** |
3/27 (11.1) |
3 (30) |
0 |
0.02 |
| Vimentin |
16/18 (88.9) |
8 (88.9) |
8 (88.9) |
ns |
| Cytokeratin |
1/19 (5.3) |
0 (0) |
1 (10.0) |
ns |
| Desmin |
4/16 (25.0) |
3 (33.3) |
1 (14.3) |
ns |
| SMA |
1/18 (5.6) |
1 (12.5) |
0 (0) |
ns |
| CD 34 |
35/36 (97.2) |
16 (94.1) |
19 (100) |
ns |
| CD 99 |
14/18 (77.8) |
5 (55.6) |
9 (100.0) |
ns |
| bcl-2 |
21/22 (95.5) |
8 (88.9) |
13 (100.0) |
ns |
| S-100 | 0/23 (0) | 0 (0) | 0 (0) | ns |
Values are N (%) or median (IQR) where applicable.
*Chi-quare test; ns, not significant; HPF, high-power field; SMA, smooth muscle antigen; bcl-2, B-cell lymphoma 2 protein; **Proliferations rate is determined by Ki-67 expression (MIB-1 labeling index).