Table 3.
Investigated variables with a possible impact on the outcome of patients with solitary fibrous tumors of the pleura
|
Variable |
HR |
CI |
p
-value* |
|---|---|---|---|
| Univariate analysis | |||
| Gender |
0.54 |
0.89-3.26 |
ns |
| Age |
1.13 |
0.91-1.30 |
ns |
| History of smoking |
2.26 |
0.29-2.35 |
ns |
| Symptomatic SFTP |
1.19 |
0.20-7.14 |
ns |
| Inhomogeneous appearance on CT |
4.69 |
0.48-45.52 |
ns |
| Sessile SFTP |
3.90 |
0.43-35.04 |
ns |
| Necrosis or hemorrhage |
0.14 |
0.02-1.31 |
ns |
| Atypical localization |
0.04 |
0.03-4.3 |
ns |
| Malignant SFTP according to Okike classification [2] |
0.21 |
0.02-2.00 |
ns |
| Pleomorphism |
0.45 |
0.07-2.74 |
ns |
| Desmin |
2.35 |
0.43-5.34 |
ns |
| Vimentin |
3.65 |
0.33-40.32 |
ns |
| CD 34 |
1.0 |
0.8-2.2 |
ns |
| CD 99 |
4.84 |
0.44-53.81 |
ns |
| Bcl-2 |
5.32 |
0.87-7.34 |
ns |
| SMA |
2.29 |
0.03-8.54 |
ns |
| Tumor diameter ≥ 10 cm |
1.24 |
1.04-1.47 |
0.015** |
| ≥ 10 mitotic figures/10 HPF |
1.33 |
1.08-1.63 |
0.008** |
| Proliferation rate ≥ 12%*** |
1.09 |
1.02-1.16 |
0.015** |
|
Multivariate analysis |
|
|
|
| Tumor diameter ≥ 10 cm |
12.45 |
0.28-5578.61 |
ns |
| ≥ 10 mitotic figures/10 HPF |
2.29 |
0.29-18.12 |
ns |
| Proliferation rate ≥ 12%*** | 1.53 | 0.35-6.64 | ns |
*Cox regression analysis; **Variables with a p-value ≤ 0.05 were entered into the multivariate analysis; ***Determined by Ki-67 expression (MIB-1 labeling index); HR, hazard ratio; CI, confidence interval; CT, computed tomography; ns, not significant; HPF, high-power field, SFTP, solitary fibrous tumor of the pleura; SMA, smooth muscle antigen; bcl-2, B-cell lymphoma 2 protein.