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. 2014 Jul 9;4:12. doi: 10.1186/2045-9912-4-12

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Copyright © 2014 Hu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Multiple HBO treatment improved spatial learning and memory abilities in hydrocephalic animals. When compared with Sham group, the animals in SAH w/t HyC group had a significantly greater distance moved from the target (A), need more time to reach the platform (B), showed less frequency in target quadrants (C), spent less time in the probe quadrants (D). Hydrocephalus exacerbated the performance. Multiple HBO treatment did not showed significant improvement of memory and learning abilities when compared with SAH/HyC group, but removed the difference between SAH w/t HyC group. Sham, n = 8; SAH w/t HyC, n = 6; SAH/HyC, n = 4; SAH/HyC + HBO, n = 4; SAH/HyC + NBO, n = 4. *p < 0.05 compared with Sham, #p < 0.05 compared with SAH w/t HyC.