Table 2.
Up-regulated genes related with functions and phenotypes of CIK IL-15
| Gene symbol | Description | Log 2 FC | P value | FDR | Go Term |
|---|---|---|---|---|---|
|
Wnt 4 |
Protein Wnt-4 |
1.10 |
3.61 × 10−4 |
7.28 × 10−3 |
Regulation of cell-cell adhesion; Wnt signaling pathway; immature T cell proliferation in thymus; positive regulation of focal adhesion assembly; T cell differentiation in thymus; cell differentiation; cell-cell signaling; negative regulation of apoptotic process; positive regulation of transcription, DNA-templated |
|
IL21R |
Interleukin 21 receptor |
1.17 |
2.53 × 10−4 |
5.53 × 10−3 |
Interleukin-21-mediated signaling pathway; natural killer cell activation; cytokine-mediated signaling pathway |
|
DTX4 |
E3 ubiquitin-protein ligase |
2.65 |
2.02 × 10−3 |
2.82 × 10−2 |
Regulation of type I interferon production; positive regulation of type I interferon production; Notch signaling pathway; innate immune response; protein ubiquitination |
|
ICAM4 |
Intercellular adhesion molecule 4 |
1.90 |
1.46 × 10−4 |
3.51 × 10−3 |
Cell adhesion; cell-cell adhesion; regulation of immune response |
| PDGFD | Platelet-derived growth factor D | 1.65 | 2.38 × 10−5 | 8.11 × 10−4 | Platelet-derived growth factor receptor signaling pathway; cellular response to amino acid stimulus; multicellular organismal development; regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division |