Table 3.

Up-regulated genes related with functions and phenotypes of CIK _IL-2

Gene symbol	Description	Log 2 FC	P value	FDR	Go terms
CTLA4	Cytotoxic T-lymphocyte-associated protein 4	1.01	1.64 × 10−3	2.38 × 10−2	Immune response; negative regulation of regulatory T cell differentiation; negative regulation of B cell proliferation; T cell costimulation; B cell receptor signaling pathway; cellular response to DNA damage stimulus; positive regulation of apoptotic process
CD80	CD80 antigen	1.03	1.11 × 10−3	1.75 × 10−2	Innate immune response; positive regulation of GMCSF biosynthetic process; positive regulation of T-helper 1 cell differentiation; T cell activation; regulation of interleukin-2 biosynthetic process; T cell costimulation
TNFSF10	Tumor necrosis factor ligand superfamily member 10	1.24	7.02 × 10−18	4.45 × 10−15	Immune response; activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of extrinsic apoptotic; signaling pathway in absence of ligand; apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process
CD40L	CD40 ligand	2.08	2.32 × 10−6	1.18 × 10−4	Immune response; inflammatory response; immunoglobulin secretion; positive regulation of endothelial cell apoptotic process; B cell proliferation; positive regulation of interleukin-12 production; leukocyte cell-cell adhesion
IRF7	Interferon regulatory factor 7	1.08	3.12 × 10−5	1.02 × 10−3	Innate immune response; inflammatory response; positive regulation of type I interferon-mediated signaling pathway; positive regulation of type I interferon production; toll-like receptor signaling pathway