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. 2014 Aug 15;9(8):e104017. doi: 10.1371/journal.pone.0104017

Figure 5. Cartoon view of a model for how monomeric NOD1 CARD could bind linear di-Ub generated by the ZDOCK server (see Materials and Methods).

Figure 5

The sidechains of Phe4 (purple) and Ile44 (black) from Ub and Cys59 (red) and Tyr88 (green) are shown as spheres. The combination of the previously identified NMR Ub-binding site (Tyr88:Ile44) with the new Ub-binding site observed in our crystal structure (Cys59:Phe4) may explain the mechanism by which NOD1 CARD preferentially binds linear and Lys63-linked poly-Ub.