Figure 5.

Identification of influenza viruses within a heterogeneous particle mixture. (a) Schematic view of the virus/nanobead mixture and nanopore. (b) Electrical blockade (top) and spectrally resolved optical fluorescence signals from viruses (center; red fluorescence) and nanobeads (bottom; blue). (c) Scatter plot of electrical signals suggesting nearly identical blockade depths but particle-dependent dwell times. (d) Cross-correlations of the optical and electrical virus detection signals for various combinations of dwell-time/spectral subpopulations, enabling unambiguous identification and assignment of viruses to long (>4 ms) dwell times.