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. 2014 Aug 15;9(8):e104011. doi: 10.1371/journal.pone.0104011

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© 2014 Tsai et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The red contour in these images represents the position of WMHs delineated semi-automatically by the experienced neurologist. (A) An FLAIR image. (B) The registered T1w image. (C) The probabilistic map representing the gray matter segmented from B. (D) The probabilistic map representing the white matter segmented from B. (E) The registered T1w image after being fused with the FLAIR image. (F) The probabilistic map representing the gray matter segmented from E. (G) The probabilistic map representing the white matter segmented from E. Note that in the probability maps, higher intensity corresponds to higher probability.