Figure 2. Correction of APC-inhibited thrombin generation by ^superFVa and wt-FVa.

Thrombin generation was determined in normal human plasma at increasing concentrations of ^superFVa or wt-FVa in the presence of rhAPC (5 nM). Thrombin generation was expressed as the relative change in the endogenous thrombin potential (ETP) in the absence of APC. Error bars represent standard error of the mean (n = 3–4).