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. 2014 Aug 15;9(8):e104516. doi: 10.1371/journal.pone.0104516

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© 2014 Barcelos Figueiredo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(Top) A diagram of the DENV-2 envelope protein showing its three protein domains (I, II and III). (Bottom) A partial alignment of the envelope protein showing sites of amino acid polymorphism within the American-Asian genotype. Other DENV-2 genotypes (Asian I, Asian II, Cosmopolitan and American) are shown for comparison. Amino acid sites in blue boxes are those that most likely had underwent a non-synonymous mutation after the divergence of the two lineages because they differ from the two ancient American-Asian DENV-2 samples (Jamaica/M20558/1983 and Puerto Rico/AY484607/1988). Amino acids are colored according to their side chain charge (hydrophobic: yellow; polar: green; negatively charged: red; and positively charged: blue).