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. 2014 Aug 15;9(8):e104503. doi: 10.1371/journal.pone.0104503

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© 2014 Yan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A-D) Immunostaining of Smad4 in the control (A and C, Tbx18^Cre/+;Smad4^f/+) and mutant ureters (B and D, Smad4^CKO) in the proximal and distal positions at E15.5. Arrowheads indicate urothelium and arrows indicate ureteral mesenchyme and SMCs.