Fig. 6.

Kinetic modeling. a, b Patlak plots for the CTRL (a) and the RGD (b) nanoemulsion including the fits to 2 intervals (300–700 s in dark grey, and 700–1,296 s in black) which were considered linear in the RGD nanoemulsion Patlak plot upon visual inspection. The first 300 s (in light grey) were omitted from analysis as this is assumed to be the vascular phase. c, d Tofts model fits (solid lines) to the DCE-MRI data (filled circles). In c the total curves were analyzed and in d the first 4.5 min post injection were fitted