Figure 4. CaMKIIβ KO have impaired motor function.

(A) CaMKIIβ KO mice show impaired forelimb grip strength but not hindlimb grip strength. The CaMKIIβ were impaired on the rotorod (B) and on the balance beam (C). No difference in spontaneous movement was seen in the open field task (D), but spontanous activity in the running wheel was decreased (E). *p<0.05, **p<0.01. Data are presented as means ±SEM. Number of mice per group is indicated on each graph.