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. 2014 Aug 15;9(8):e105381. doi: 10.1371/journal.pone.0105381

Figure 4. Over-expression of C/EBPβ reverses c-Myc induced drug resistance.

Figure 4

(A) NB4/GFP and NB4/MYC cells were treated with 1 µM ATRA for 72 h. Expression of c-Myc, C/EBPβ was tested by RT-PCR and Western blot assay. GAPDH was used as an internal control. (B) C/EBPβ was over-expressed in NB4/MYC cells (NB4/MYC C/EBPβ). Western blotting analysis was performed to detect expression of C/EBPβ (a). NB4/MYC C/EBPβ cells were treated with Ara-C (0.1 µM), DNR (0.2 µg/ml) or Doxo (0.04 µg/ml) for 48 h. Drug sensitivity was testified by MTT assay (b–d). Data summarized three independent experiments. **p<0.01, ***p<0.001, Student's t test.