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. 2014 Aug 15;9(8):e105383. doi: 10.1371/journal.pone.0105383

Figure 3. MTA workflow.

Figure 3

MTA performs knockouts for each of the reactions in the metabolic model at the AD state (source), and assigns a score for each gene knockout reflecting the predicted extent by which this knockout may transform the metabolic state back to the healthy (target) state. Next, we aggregate the gene/reaction level predictions to identify the pathways whose knockout is predicted to be most successful in transforming the metabolic state as close as possible back to the healthy state.