Table 2. Selection signatures in the 7 geographical groups.
OAR | Begin (Mbp) | End (Mbp) | P-value | Q-value | Group | Test | Diff. pop. | Cand. gene | Nr. genes | Rank |
2 | 46.65 | 57.99 | 6.3e-10 | 7.1e-07 | ITA | hapFLK | COM | NPR2† | 85 | 15 |
2 | 51.41 | 53.44 | 4.1e-09 | 1.6e-04 | ITA | FLK | COM | 41 | 2 | |
2 | 74.00 | 74.86 | 7.4e-04 | 3.7e-02 | ITA | hapFLK | COM | 7 | ||
2 | 81.27 | 87.32 | 4.1e-09 | 2.3e-06 | ITA | hapFLK | COM | BNC2 | 18 | 1 |
2 | 110.08 | 112.08 | 1.5e-05 | 6.7e-02 | ASI | FLK | SUM TIB GUR | 11 | ||
2 | 113.36 | 122.24 | 7.0e-06 | 3.3e-03 | NEU | hapFLK | GTX NTX STX | MSTN† | 42 | 8 |
2 | 239.76 | 241.76 | 2.9e-05 | 9.3e-02 | SWA | FLK | AFS | RUNX3 | 33 | 1 |
3 | 84.40 | 86.40 | 2.5e-05 | 9.1e-02 | ASI | FLK | 15 | |||
3 | 120.91 | 125.49 | 5.3e-04 | 3.0e-02 | ITA | hapFLK | COM | KITLG | 5 | 5 |
3 | 122.07 | 130.85 | 6.8e-08 | 4.2e-04 | AFR | hapFLK | 25 | 1 | ||
3 | 151.42 | 156.93 | 3.3e-16 | 3.1e-12 | ITA | hapFLK | COM SAB | HMGA2† | 26 | 1 |
3 | 154.79 | 154.93 | 5.9e-04 | 4.3e-02 | AFR | hapFLK | 12 | 12 | ||
3 | 159.64 | 161.60 | 6.1e-04 | 3.3e-02 | ITA | hapFLK | COM | 6 | ||
3 | 167.85 | 171.67 | 1.5e-04 | 1.3e-02 | ITA | hapFLK | COM ALT SAB | 27 | ||
4 | 4.61 | 6.61 | 5.3e-06 | 2.1e-02 | SWA | FLK | MOG | 8 | ||
4 | 8.50 | 19.66 | 4.2e-06 | 1.1e-03 | CEU | hapFLK | VBS VRS | 49 | ||
4 | 15.11 | 17.11 | 8.4e-07 | 1.5e-02 | CEU | FLK | VBS | 7 | ||
4 | 26.46 | 28.46 | 2.4e-05 | 9.1e-02 | ASI | FLK | GUR IDC SUM | HDAC9 | 6 | 1 |
4 | 44.49 | 45.76 | 2.7e-04 | 3.4e-02 | NEU | hapFLK | NZR | 12 | ||
4 | 45.57 | 47.57 | 1.8e-06 | 2.4e-02 | ASI | FLK | SUM | 8 | ||
4 | 67.75 | 69.80 | 3.5e-07 | 2.3e-03 | SWA | FLK | MOG | HOXA | 18 | 2→10 |
5 | 29.40 | 31.40 | 1.1e-05 | 6.7e-02 | ASI | FLK | GAR | 3 | ||
5 | 47.35 | 49.35 | 1.4e-05 | 6.7e-02 | ASI | FLK | BGA | 35 | ||
5 | 78.16 | 78.76 | 4.2e-04 | 4.2e-02 | NEU | hapFLK | NZT | 16 | ||
6 | 5.62 | 7.62 | 3.1e-06 | 6.0e-02 | ITA | FLK | SAB | 11 | ||
6 | 33.22 | 41.02 | 3.4e-08 | 8.0e-05 | SWE | hapFLK | LAC LAM | ABCG2†/NCAPG | 27 | 2/17 |
6 | 34.71 | 39.12 | 1.6e-07 | 4.1e-05 | ITA | hapFLK | COM | 23 | 11/2 | |
6 | 35.94 | 38.31 | 2.1e-04 | 1.9e-02 | CEU | hapFLK | VRS VBS | 19 | 9/17 | |
6 | 67.98 | 70.36 | 4.3e-06 | 1.1e-03 | CEU | hapFLK | VBS | KIT† | 9 | 5 |
6 | 68.90 | 70.95 | 9.6e-07 | 5.3e-03 | SWA | FLK | 10 | 2 | ||
6 | 93.30 | 94.39 | 3.8e-04 | 2.7e-02 | CEU | hapFLK | VRS&VBS or ERS&BOS | FGF5† | 8 | 5 |
7 | 49.15 | 51.15 | 1.1e-05 | 9.7e-02 | CEU | FLK | VRS | 7 | ||
7 | 78.31 | 80.31 | 8.1e-07 | 1.5e-02 | CEU | FLK | VRS ERS | 13 | ||
8 | 23.97 | 25.97 | 2.9e-05 | 9.6e-02 | ASI | FLK | TIB | 6 | ||
9 | 29.46 | 31.55 | 3.7e-04 | 3.4e-02 | SWE | hapFLK | CHU MER | 1 | ||
9 | 37.79 | 46.03 | 1.9e-05 | 6.2e-03 | NEU | hapFLK | NZT ISF | 6 | ||
10 | 24.02 | 34.91 | 1.4e-14 | 1.1e-10 | CEU | hapFLK | BOS ERS VRS | RXFP2† | 68 | 9 |
10 | 29.42 | 29.71 | 9.6e-04 | 4.4e-02 | ITA | hapFLK | COM ALT | 14 | 2 | |
10 | 28.50 | 30.50 | 6.3e-06 | 7.5e-02 | CEU | FLK | BOS ERS | 14 | 1 | |
10 | 28.50 | 30.50 | 3.2e-05 | 9.7e-02 | SWA | FLK | NDZ | 14 | 1 | |
10 | 28.50 | 30.50 | 1.3e-06 | 5.4e-02 | SWE | FLK | MER | 14 | 1 | |
10 | 48.90 | 49.59 | 5.2e-04 | 3.1e-02 | CEU | hapFLK | 3 | |||
11 | 12.55 | 14.12 | 1.4e-04 | 2.2e-02 | NEU | hapFLK | 33 | |||
11 | 24.18 | 38.74 | 9.8e-09 | 8.0e-05 | SWE | hapFLK | LAC MER | 296 | ||
11 | 40.31 | 46.70 | 3.3e-06 | 5.5e-04 | ITA | hapFLK | SAB | 164 | ||
12 | 42.66 | 44.66 | 3.4e-07 | 7.6e-03 | ASI | FLK | SUM | 10 | ||
13 | 33.10 | 40.02 | 5.7e-06 | 1.8e-03 | AFR | hapFLK | 41 | |||
13 | 40.60 | 50.30 | 4.9e-07 | 4.9e-04 | AFR | hapFLK | BMP2† | 76 | 1 | |
13 | 43.34 | 51.28 | 2.7e-07 | 1.7e-04 | SWE | hapFLK | LAC LAM | PRNP | 49 | 8 |
13 | 56.11 | 57.17 | 2.5e-08 | 4.8e-04 | SWA | hapFLK | MOG | EDN3 | 19 | 1 |
13 | 55.33 | 57.43 | 8.4e-11 | 1.1e-06 | SWA | FLK | MOG | 19 | 1 | |
14 | 6.37 | 13.60 | 1.6e-04 | 1.4e-02 | ITA | hapFLK | SAB | 70 | ||
14 | 13.64 | 13.70 | 5.3e-04 | 4.9e-02 | NEU | hapFLK | ISF | MC1R | 48 | 33 |
14 | 13.70 | 16.46 | 1.2e-04 | 1.1e-02 | ITA | hapFLK | SAB | 37 | 21 | |
14 | 45.49 | 50.09 | 1.6e-04 | 2.5e-02 | NEU | hapFLK | NTX NZR | 117 | ||
15 | 48.87 | 50.87 | 1.5e-05 | 6.7e-02 | ASI | FLK | GAR IDC | 36 | ||
15 | 71.71 | 73.71 | 3.8e-06 | 1.6e-02 | SWA | FLK | MOG | ALX4/EXT2 | 13 | 1/3 |
16 | 33.20 | 35.10 | 1.8e-04 | 1.8e-02 | AFR | hapFLK | C6/C7 | 8 | 5/7 | |
16 | 63.97 | 65.97 | 1.1e-05 | 6.7e-02 | ASI | FLK | GAR IDC | 5 | ||
19 | 4.42 | 7.43 | 2.2e-04 | 1.9e-02 | CEU | hapFLK | VRS BOS | GLB1† | 17 | 14 |
19 | 30.42 | 35.09 | 3.2e-05 | 4.2e-03 | CEU | hapFLK | VBS BOS ERS | MITF† | 14 | 9 |
19 | 44.60 | 46.60 | 3.9e-06 | 3.9e-02 | ASI | FLK | GAR BGA | WNT5A | 4 | 1 |
20 | 36.74 | 38.52 | 2.8e-04 | 2.3e-02 | CEU | hapFLK | VRS | 10 | ||
22 | 18.90 | 24.36 | 1.5e-11 | 7.4e-08 | NEU | hapFLK | GTX | PITX3‡ | 85 | 5 |
23 | 42.50 | 46.96 | 2.2e-05 | 5.4e-03 | AFR | hapFLK | MC2R/MC5R | 35 | 1/2 | |
23 | 54.14 | 56.14 | 3.8e-07 | 7.6e-03 | ASI | FLK | GAR | 5 | ||
25 | 0.08 | 3.08 | 3.7e-04 | 2.4e-02 | ITA | hapFLK | SAB | 16 |
Regions identified with the hapFLK or FLK test, with the corresponding population group and most differentiated populations (except for the AFR group). Full names of groups and populations are given in Table 1. The number of genes included in each region and the rank of candidate genes within the region is also provided. Overlapping regions detected in different population groups or with different tests are grouped within horizontal lines (in this case candidate genes are the same for all overlapping regions and are only reported in the first one). : signatures of selection previously identified [4]. : this outlying region is not due to evolutionary processes (see details in the main text).