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. 2014 Aug 15;9(8):e103813. doi: 10.1371/journal.pone.0103813

Table 2. Selection signatures in the 7 geographical groups.

OAR Begin (Mbp) End (Mbp) P-value Q-value Group Test Diff. pop. Cand. gene Nr. genes Rank
2 46.65 57.99 6.3e-10 7.1e-07 ITA hapFLK COM NPR2† 85 15
2 51.41 53.44 4.1e-09 1.6e-04 ITA FLK COM 41 2
2 74.00 74.86 7.4e-04 3.7e-02 ITA hapFLK COM 7
2 81.27 87.32 4.1e-09 2.3e-06 ITA hapFLK COM BNC2 18 1
2 110.08 112.08 1.5e-05 6.7e-02 ASI FLK SUM TIB GUR 11
2 113.36 122.24 7.0e-06 3.3e-03 NEU hapFLK GTX NTX STX MSTN† 42 8
2 239.76 241.76 2.9e-05 9.3e-02 SWA FLK AFS RUNX3 33 1
3 84.40 86.40 2.5e-05 9.1e-02 ASI FLK 15
3 120.91 125.49 5.3e-04 3.0e-02 ITA hapFLK COM KITLG 5 5
3 122.07 130.85 6.8e-08 4.2e-04 AFR hapFLK 25 1
3 151.42 156.93 3.3e-16 3.1e-12 ITA hapFLK COM SAB HMGA2† 26 1
3 154.79 154.93 5.9e-04 4.3e-02 AFR hapFLK 12 12
3 159.64 161.60 6.1e-04 3.3e-02 ITA hapFLK COM 6
3 167.85 171.67 1.5e-04 1.3e-02 ITA hapFLK COM ALT SAB 27
4 4.61 6.61 5.3e-06 2.1e-02 SWA FLK MOG 8
4 8.50 19.66 4.2e-06 1.1e-03 CEU hapFLK VBS VRS 49
4 15.11 17.11 8.4e-07 1.5e-02 CEU FLK VBS 7
4 26.46 28.46 2.4e-05 9.1e-02 ASI FLK GUR IDC SUM HDAC9 6 1
4 44.49 45.76 2.7e-04 3.4e-02 NEU hapFLK NZR 12
4 45.57 47.57 1.8e-06 2.4e-02 ASI FLK SUM 8
4 67.75 69.80 3.5e-07 2.3e-03 SWA FLK MOG HOXA 18 2→10
5 29.40 31.40 1.1e-05 6.7e-02 ASI FLK GAR 3
5 47.35 49.35 1.4e-05 6.7e-02 ASI FLK BGA 35
5 78.16 78.76 4.2e-04 4.2e-02 NEU hapFLK NZT 16
6 5.62 7.62 3.1e-06 6.0e-02 ITA FLK SAB 11
6 33.22 41.02 3.4e-08 8.0e-05 SWE hapFLK LAC LAM ABCG2†/NCAPG 27 2/17
6 34.71 39.12 1.6e-07 4.1e-05 ITA hapFLK COM 23 11/2
6 35.94 38.31 2.1e-04 1.9e-02 CEU hapFLK VRS VBS 19 9/17
6 67.98 70.36 4.3e-06 1.1e-03 CEU hapFLK VBS KIT† 9 5
6 68.90 70.95 9.6e-07 5.3e-03 SWA FLK 10 2
6 93.30 94.39 3.8e-04 2.7e-02 CEU hapFLK VRS&VBS or ERS&BOS FGF5† 8 5
7 49.15 51.15 1.1e-05 9.7e-02 CEU FLK VRS 7
7 78.31 80.31 8.1e-07 1.5e-02 CEU FLK VRS ERS 13
8 23.97 25.97 2.9e-05 9.6e-02 ASI FLK TIB 6
9 29.46 31.55 3.7e-04 3.4e-02 SWE hapFLK CHU MER 1
9 37.79 46.03 1.9e-05 6.2e-03 NEU hapFLK NZT ISF 6
10 24.02 34.91 1.4e-14 1.1e-10 CEU hapFLK BOS ERS VRS RXFP2† 68 9
10 29.42 29.71 9.6e-04 4.4e-02 ITA hapFLK COM ALT 14 2
10 28.50 30.50 6.3e-06 7.5e-02 CEU FLK BOS ERS 14 1
10 28.50 30.50 3.2e-05 9.7e-02 SWA FLK NDZ 14 1
10 28.50 30.50 1.3e-06 5.4e-02 SWE FLK MER 14 1
10 48.90 49.59 5.2e-04 3.1e-02 CEU hapFLK 3
11 12.55 14.12 1.4e-04 2.2e-02 NEU hapFLK 33
11 24.18 38.74 9.8e-09 8.0e-05 SWE hapFLK LAC MER 296
11 40.31 46.70 3.3e-06 5.5e-04 ITA hapFLK SAB 164
12 42.66 44.66 3.4e-07 7.6e-03 ASI FLK SUM 10
13 33.10 40.02 5.7e-06 1.8e-03 AFR hapFLK 41
13 40.60 50.30 4.9e-07 4.9e-04 AFR hapFLK BMP2† 76 1
13 43.34 51.28 2.7e-07 1.7e-04 SWE hapFLK LAC LAM PRNP 49 8
13 56.11 57.17 2.5e-08 4.8e-04 SWA hapFLK MOG EDN3 19 1
13 55.33 57.43 8.4e-11 1.1e-06 SWA FLK MOG 19 1
14 6.37 13.60 1.6e-04 1.4e-02 ITA hapFLK SAB 70
14 13.64 13.70 5.3e-04 4.9e-02 NEU hapFLK ISF MC1R 48 33
14 13.70 16.46 1.2e-04 1.1e-02 ITA hapFLK SAB 37 21
14 45.49 50.09 1.6e-04 2.5e-02 NEU hapFLK NTX NZR 117
15 48.87 50.87 1.5e-05 6.7e-02 ASI FLK GAR IDC 36
15 71.71 73.71 3.8e-06 1.6e-02 SWA FLK MOG ALX4/EXT2 13 1/3
16 33.20 35.10 1.8e-04 1.8e-02 AFR hapFLK C6/C7 8 5/7
16 63.97 65.97 1.1e-05 6.7e-02 ASI FLK GAR IDC 5
19 4.42 7.43 2.2e-04 1.9e-02 CEU hapFLK VRS BOS GLB1† 17 14
19 30.42 35.09 3.2e-05 4.2e-03 CEU hapFLK VBS BOS ERS MITF† 14 9
19 44.60 46.60 3.9e-06 3.9e-02 ASI FLK GAR BGA WNT5A 4 1
20 36.74 38.52 2.8e-04 2.3e-02 CEU hapFLK VRS 10
22 18.90 24.36 1.5e-11 7.4e-08 NEU hapFLK GTX PITX3 85 5
23 42.50 46.96 2.2e-05 5.4e-03 AFR hapFLK MC2R/MC5R 35 1/2
23 54.14 56.14 3.8e-07 7.6e-03 ASI FLK GAR 5
25 0.08 3.08 3.7e-04 2.4e-02 ITA hapFLK SAB 16

Regions identified with the hapFLK or FLK test, with the corresponding population group and most differentiated populations (except for the AFR group). Full names of groups and populations are given in Table 1. The number of genes included in each region and the rank of candidate genes within the region is also provided. Overlapping regions detected in different population groups or with different tests are grouped within horizontal lines (in this case candidate genes are the same for all overlapping regions and are only reported in the first one). Inline graphic: signatures of selection previously identified [4]. Inline graphic: this outlying region is not due to evolutionary processes (see details in the main text).