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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: Nature. 2014 Jul 6;512(7513):208–212. doi: 10.1038/nature13401

Figure 4. Loss of DENR leads to reduced InR and EcR protein levels and signaling.

Figure 4

(a) DENR and MCT-1 knockdown cells have reduced InR and EcR protein levels. (b-c) DENR-KD cells are less sensitive to insulin stimulation (1 h) (b) and to ecdysone (1 μM, 4 h; c). (d-e) Expression of EcR (d) or InR (e) in histoblast cells and imaginal discs of DENRKO using escargot-GAL4 rescues their delayed pupation (d) and mildly but significantly their proliferation defect (e). Error bars: std dev. ***t-test<0.001